Scale-up considerations for improved yield in upstream viral vector production

Production Scale Up of Nanofibers: A Review

HIV transmission in MSM: considerations for PrEP scale-up.

e62 www.thelancet.com/hiv Vol 3 February 2016 The modelling exercises described in Narat Punyacharoensin and colleagues’ study in The Lancet HIV show the value of incorporation of pre-exposure prophylaxis (PrEP) into combination HIV prevention in men who have sex with men (MSM). Through a well conceived set of simulations, the investigators examined the number of infections that could be averte...

Scale-up considerations for monoclonal antibody production process: an oxygen transfer flux approach

Background When scaling up a monoclonal antibody (mAb) production process in stirred tank bioreactor, oxygen transfer is probably one of the most challenging parameters to consider. Approaches such as keeping constant specific power input or tip speed across the scales are widely described in the literature and are often based on the assumption that mammalian cells are sensitive to shear stress...

production scale up of nanofibers: a review

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Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale

Introduction Wild-type or recombinant viruses used as vaccines and human gene therapy vectors are an important development tool in modern medicine. Some have demonstrated high potential such as lentivirus, paramyxovirus and adeno-associated-virus (AAV). These vectors are produced in adherent and suspension cell cultures (e.g. HEK293T, A549, VERO, PER.C6, Sf9) using either transient transfection...